(Enlargement of the pituitary tissue created from embryonic stem cells. Image: Yoshiki Sasai)

The adenohypophysis or anterior pituitary functions as an important center of production of hormones. At present, no type of stem cell culture is capable of generating this type of tissue in humans, but Japanese scientists have just successfully in mice and intend to create a human pituitary in the next three years.

One of the authors of the study, Yoshiki Sasai, the group of Neurogenesis and Organogenesis of the Riken Center for Developmental Biology (Kobe, Japan) has explained to SINC that “as an extension of this success, we plan to apply our technology to human stem cells from the ES (embryonic) and IPS (induced pluripotent). We hope to develop an efficient method for producing human pituitary in the coming years. “

The mouse embryonic stem cells were stimulated in a culture that mimicked three-dimensional tissue interactions, to thereby produce the five hormones generated by different cell types present in the pituitary. The corticotrophic, for example, showed they were capable of secreting the hormone adenocorticotrópica in response to corticotropin-releasing hormone.

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