The regulation of p21 promotes the state induced pluripotent cells of mammals, a clear correlation between stem cells, tissue regeneration and cell cycle
A search lasted more than a decade has given rise to a fundamental discovery in biology: a gene that regulates tissue regeneration in mammals. The absence of this single gene, called p21, mice engineered to give a capacity restraint so far lost during evolution, is reserved for organisms such as flatworms, sponges and some species of salamanders: the regeneration of damaged tissues.
In now published an article on Proceedings of the National Academy of Sciences, Researchers at the Wistar Institute report that as lack of this gene allows the mice to form a blastema, a structure associated with rapid cell growth and differentiation, as observed in amphibians.
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Only seven species of mammals, all rodents, have an unusual mechanism of sex determination which involves the development of fertile females with XY chromosomes
In mammals, sex determination generally follows a very simple rule: If you have XX chromosomes develops a female with XY chromosomes develops instead a male. In situations where there is a deviation from this principle speaks of chromosomal abnormalities that often cause infertility. On the Y chromosome, sex is determined by the presence or absence of a single gene, called Sry, Identified in 1990. This gene triggers the development of masculine characteristics, while in his absence the gonads become ovaries.
Only a few species of mammals are beyond the rule, have hitherto been known only seven, all belonging to rodents.
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