Chinese researchers have found that prolonged exposure to IL -1 molecule , known as the “molecule of fever , may also cause tissue damage , as in many autoinflammatory diseases . These findings, published in the online edition of the journal Nature ImmunologyCould lead to the development of new treatments.
A key inflammatory molecule , interleukin 1 (IL- 1) has been called the “molecule of fever “because its release results in increased body temperature, in addition to activating immune cells to fight infection. But a new study by researchers at Tsinghua University in Beijing (China ), reveals that prolonged exposure can also cause other damage.
Thus the work , published today in the online edition of the journal Nature Immunology Shows that the “molecule of fever “can cause a deterioration in the tissues , as in many autoinflammatory diseases such as rheumatoid arthritis .
The team, led by Wang Xinquan , has figured out how IL- 1beta , a very important form of IL -1, activator binds to its receptor IL- 1RI – signaling that promotes inflammation – and IL- receptor inhibitor 1RII – which reduces the signs of inflammation.
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