Glässer disease is a reemerging disease of pigs Glässer disease caused by the bacterium Haemophilus parasuis. The use of vaccines to combat the disease is limited by a lack of protection against all variants of the bacteria. The trimeric autotransporters are proteins exposed to the outside of the bacteria, so it can be used as vaccines. These proteins are also found in H. parasuis and are called selftrimeric transporters associated with virulence (VtaA using the acronym).

In this project we sought the presence of antibodies in the blood of animals that had survived infection with H. parasuis. It was found that animals that failed to develop the disease, despite being exposed to live bacteria, developed antibodies against 8 of the 15 VtaA analyzed.

When pigs were exposed to bacteria cultured in the laboratory, instead of living dead, did not create new antibodies against VtaA. This fact shows that the bacteria produces VtaA only when in contact with the pig. In summary, these results show that VtaA are candidates to be part of future vaccines Glässer disease.

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Source: Centre for Research in the Animal Health